Hi gwy15
Most likely this is caused by a security feature in Windows 10 . . .
Open Windows Defender Security Center
Go to Virus & threat protection - Virus & threat protection settings
Scroll down to Controlled folder access
Temporarily turn off Controlled Folder Access and check to see if you can save (read/write) to those locations
If so, from there, you can add an application to the list of safe or allowed apps to prevent them from being blocked
Please do not leave Controlled Folder Access turned off permanently