Core isolation is another Windows 10 feature that, in my opinion, was put there to save people who are not otherwise able to save themselves. While it does work, it interferes with Windows' normal operation (by design) which can occasionally cause trouble, particularly for the intended user base.
Here is, again, in my opinion, the correct way to protect against ransomware: Instead of enabling core isolation, backup the C: drive every day (if not more frequently) with an image application that locks the backup archive from being changed.
Then, if your computer is struck by ransomware, which is getting tougher to avoid, simply format the C: drive and restore your backup.