Hi,
Should be possible to monitor with a single monitoring solution, Azure Stack Hub includes infra monitoring capabilities by itself.
Monitor health and alerts in Azure Stack Hub
https://learn.microsoft.com/en-us/azure-stack/operator/azure-stack-monitor-health?view=azs-2002
It is also possible to integrate with external monitoring software like System Center Operations Manager (SCOM) or Nagios.
Azure Stack Hub software offers a REST-based API to retrieve health and alerts. The use of software-defined technologies such as Storage Spaces Direct, storage health, and alerts are part of software monitoring.
More information here:
Integrate external monitoring solution with Azure Stack Hub
https://learn.microsoft.com/en-us/azure-stack/operator/azure-stack-integrate-monitor?view=azs-2002
Best regards,
Leon