Should be possible to monitor with a single monitoring solution, Azure Stack Hub includes infra monitoring capabilities by itself.
Monitor health and alerts in Azure Stack Hub
It is also possible to integrate with external monitoring software like System Center Operations Manager (SCOM) or Nagios.
Azure Stack Hub software offers a REST-based API to retrieve health and alerts. The use of software-defined technologies such as Storage Spaces Direct, storage health, and alerts are part of software monitoring.
More information here:
Integrate external monitoring solution with Azure Stack Hub