I have solved it by making it a try, catch statement. Please feel free to leave a better suggestion if you have one.
try
{
if (webView21 != null && webView21.CoreWebView2 != null)
{
webView21.CoreWebView2.Navigate(textBox1.Text);
}
}
catch
{
webView21.CoreWebView2.Navigate("https://duckduckgo.com/?q=" + textBox1.Text + "&t=h_&ia=web");
}