In a like yours, I would probably recommend not using an Autonumber field. Or, if you do, at least provide another ID field to identify each unique record from each user. You can then use this information to map all the related records together.
For instance, let's say your main db has a record with ID=1. User 1 could be using something like User1ID=34 and User 2 could be using User2ID=65 to refer to MainDBID=1.
Hope that helps...