Hi,
Thanks for posting in Microsoft MECM Q&A forum.
1.When you use Configuration Manager manages the certificate option, a new certificate of type Third-party WSUS Signing is created in the Certificates node under Security in the Administration workspace. Please help check whether the certificate status is BLOCKED or UNBLOCKED status from SCCM console (\Administration\Overview \Security\Certificates). If the certificate is blocked, then there is a chance of failure in the publishing process.
2.If possible, please reboot of the site server to have a try.
Similar thread for your reference: Invalid certificate signature Error 0x800b0004 0x80073633 when Downloading Updates
Thanks for your time.
Best regards,
Simon
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