Hi,
Based on my understanding if you want to apply a GPO to users or computers, they need both the read permission and apply group policy permission.
They will not apply the group policy with the only read permission.
Under the scop you can add or remove the groups.
Under the delegation you can assign the permission on this GPO.
For example:
If you deploy the GPO with user configuration on the domain level, then all the users need the Read permission and apply group policy permission. At the same time, computers need the read permission on the GPO.
To do this:
You can either keep the default setting: authenticated users have Read permission and apply group policy permission. (Authenticated users include all the user objects and computer objects in the domain). Or you can add the user group with the Read permission, apply group policy permission, and add the computers group with the read permission.
If you deploy the GPO with computer configuration on the domain level, then all the computers need the Read permission and apply group policy permission.
You can either keep the default setting: authenticated users have Read permission and apply group policy permission. (Authenticated users include all the user objects and computer objects in the domain). Or you can add the computers group with Read permission and apply group policy permission. Users don't need the permission.
Best Regards,