Hi @p naveen kumar ,
What does xDL forrum mean? According to my research, no relevant information was found.
So how is the configuration between your application and S2? For example, how to specify the mail sent from the application to be sent to S2 for relay?
If possible, you could try to just cancel the settings and send the email directly to the Internet, and send it directly to your Office 365 through DNS resolution.
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