Chkdsk is highly unlikely to make a difference in performance. The things that will:
Programs that startup on every startup and stay running: Skype, AOL, Garmin, dropbox, Disk burner software, lots of others. If you will provide me with a list of the programs that you have installed, I can point out the main culprits to you.
Most of them allow you to change the default settings so they do NOT start on every startup. Those programs and there can be many can eat up a lot of resources. Many if not most, are programs you rarely use. If they are not started up on the startup, you can choose to start them from the menu.
Malware will affect performance. Occasionally download and run ADWcleaner. It is free and does NOT install and always run. It is not the same as your antivirus software and will often find malware that the AV did not.
Do not install more than ONE antivirus program. In fact when your current subscription is up, consider changing to one that is NOT a "security" product. All you need is the Antivirus software that is part of it. The rest of it is a real resource waster and does not make your computer safer. You may even have trouble locating AV only software. The sellers don't like to sell it because they cannot price it as highly. On top of that, security products make it very difficult if not impossible to diagnose a problem. In fact, I will not even try on a computer with it installed.
Most installed malware "protectors" are indeed resource hogs. I don't allow them on my clients' computers. Just run ADWcleaner periodically. In fact, almost all software that claims to make your computer run better/faster, does exactly the opposite.
If your disk is too full, it will slow performance. Consider 75% of its capacity to be your limit. If you use more than that, it will gradually slow performance more and more as that 75% rises.
If your disk is 60% or more in use, manually run the defragmenter. Below 60% it will not make a noticeable difference and defragmentation is a waste of time.
Reset Windows Update to Never..... Run it at your convenience when you choose to. It can otherwise badly affect pefromance. Anyway, Microsoft stopped issuing security updates for Windows 1 1/2 years ago.