Outlook 2019 profile keeps getting corrupted for 1 user

Tim Toles 96 Reputation points

I have a user that has Office 2019 (retail, not 365). Her outlook profile keeps getting corrupted. I have created new profiles numerous times, and it only works for a day. The next time the machine boots up, she gets the error "Cannot start Microsoft Outlook. Cannot open the Outlook window. The set of folders cannot be opened. The operation failed". Earlier this week I went as far as creating a new user account. No joy, still doing the same thing. She has three 365 mailboxes configured. A different user on the same machine has the same setup (3 mailboxes), and his account works flawlessly. Not sure where to go with this; if it was a 365 app, I could get MS support directly, but it's not, so I can't.

Outlook Management
Outlook Management
Outlook: A family of Microsoft email and calendar products.Management: The act or process of organizing, handling, directing or controlling something.
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  1. Tim Toles 96 Reputation points


    I tried to post this yesterday, but the site just hung when I hit post. This Q&A site is horrible. Unresponsive, slow, tedious.

    At any rate, the problem is resolved. There was a problem with permissions on one of the accounts. It's a pity that the error message was so vague and ambiguous.

    Many thanks for your time and response.

    Take care, stay safe,

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  1. Jade Liang-MSFT 9,946 Reputation points Microsoft Employee

    Hi ,

    I went as far as creating a new user account, A different user on the same machine has the same setup (3 mailboxes),

    Did you create a new windows user account or a mailbox? Did this different user configure his accounts on this machine with a same windows user profile or a different windows profile?

    Did this issue occur only recently? If so, have you performed any specific operations before it(such as install any add-ins or programs)?

    In order to avoid the interfence of COM add-ins, it's suggested to restart your Outlook in safe mode when the error prompt to check if you could work normally, if you could open it in safe mode, the issue may be related to any com add-ins, please try to disable any COM add-ins to check (File>Options>Add-ins>COM add-in, Go>uncheck it)

    If that's invalid, for Microsoft 365 user, we supply the SaRA tools to troubleshooting the "Outlook won't start" issue, it's suggested to download it to check if it could work for you.

    If your issue has any update, please feel free to post back.