Hi, Hamilton Hurst
Welcome to Microsoft Community.
We understand that you are having problems with your mouse not working in Safe Mode.
What is your mouse manufacturer and model number?Your problem is related to the mechanism of Safe Mode, in Safe Mode, Windows will only load the basic driver, so if your mouse can not be used in Safe Mode, it means that your mouse can not be used by the Microsoft Basic Driver, and it may need the manufacturer-specific driver or software to connect, can your mouse be used in the Normal Mode of Windows? Can your mouse be used in Windows Normal Mode? You can try to use other basic office USB mouse instead to fulfill your requirement in safe mode.By Load Hive, do you mean the drop-down menu for File options? If so you can press Alt+F4 and use the up and down arrow keys to select it.If it's the other directory options, you can also use the Alt+corresponding shortcut keys.If you still have questions, feel free to contact us.
Best Regards
Nicholas.Z - MSFT | Microsoft Community Support Specialist