Hello Matt, this is Emily.
It sounds like the issue is with a user profile corruption. These system paths are not meant to be modified as they have organic relationship in so many places.
To fix this new issue, it might be tedious, but I believe it can work.
Back up your user folder data located in C:\users\your username folder. Back them up to external drive for example.
Once you have the data secured. Create another local admin user. Type netplwiz in the search on the taskbar and hit enter. When launched, click on "Add". On the next window, click on the bottom where it says to create an account without Microsoft email. This will allow you to define your own username. Make sure it doesn't contain space or special character. Set it up as a local user.
When the above user is created, back to the main netplwiz page, double click on this new user, go to the Group Membership tab, make it administrator. Save the change.
Restart the computer. Sign into the new user you created
Type sysdm.cpl in the search on the taskbar and hit enter, go to Advanced tab, click on the "Settings" button at the User Profile section. Then delete the old user profile.
Restart the computer, sign into the old user. It will take a bit longer to sign in as it has to recreate your user profile. Once in, your apps and programs should work. You can then transfer your data back into your user profile folder.