You seem to know what you are doing related to adding and removing drivers from Windows Image files. So if you need larger files, a USB drive can be created with a small FAT32 partition for booting and a larger NTFS partition to accommodate the larger files.
Rufus will do that or you can do it yourself.. Maybe Greg's links cover this.. I have been wanting to verify the Rufus operation but have been unable to locate one of the Install media downloads that has a file larger than 4 GBs.