Hi,
Thank you for writing to Microsoft Community Forums.
I understand your query related to using YubiKey with Windows Hello on your PC. I will certainly try my best to assist you with the issue.
You may want to refer the articles Yubico Login for Windows Configuration Guide and Password-less Login with the YubiKey 5 Comes to Microsoft Accounts see if that helps.
Regards,
Prakhar Khare
Microsoft Community – Moderator