Hi SamP#BlueShield,
The best option is to copy off any data you need to keep temporarily to another drive, then, in Disk Management, right click each partition on that drive and select 'Delete Volume'
When the whole drive is marked as one unallocated space, right click that and choose 'New - Simple volume' and accept the defaults.
That will give you a clean drive to use as a data drive, you can then copy your files back onto it.