Setting up and managing device configurations using Intune
@MasterSprongklong Thanks for posting in our Q&A.
For this issue, it is suggested to just deploy the Configuration Profile or just deploy Defender Baseline policy to a group. It is not recommended to mix them. Some settings may affect each other even if you don't configure them. It seems a known issue.
Given this situation, it is better to create an online support ticket to double confirm and find more accurate help. It is free. Here is the online support link and hope it helpful:
https://learn.microsoft.com/en-us/mem/intune/fundamentals/get-support
Thanks for understanding.
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