Hi,
Based on my understanding, all the computer GPOs and user GPOs don't apply on this specific computer (after installation of Win 10 Pro 21H1), right?
If i misunderstand you, please feel free to let me know.
Did you check the security filter, was the computer has the read permission on the folder redirection GPO?
Are there any errors when you run gpresult /h report.html.
You may try to run the following PowerShell command and check the result:
Test-ComputerSecureChannel
Test-ComputerSecureChannel -Server "DCName.domain.com"
If the command fails, run command:
Test-ComputerSecureChannel -Repair
And then check if it repairs the issue.
If not, it will be a quick way to remove and join it to the domain again.
Best Regards,