HI ManishChawda-0385,
1.Could you please enter winver in command prompt on win10 computer and look the os version and os version number ?[for example windows 10 enterprise 1809 (os build 17763.316)]
2.What's the name of your Portable App?
We can try to use applocker policy to block the Portable App.
Configuring AppLocker in Windows Server 2019 | Active Directory Group Policy
https://www.youtube.com/watch?v=uQCuBl5xjGU
How to Use AppLocker to Allow or Block Executable Files from Running in Windows 10
https://www.tenforums.com/tutorials/124008-use-applocker-allow-block-executable-files-windows-10-a.html
Please Note: Microsoft provides third-party contact information to help you find technical support. This contact information may change without notice.
other document for your reference
https://social.technet.microsoft.com/Forums/en-US/dfd21e22-b245-4d2b-b9c7-912fe357653e/how-to-block-portable-application-amp-prevent-installation-on-active-directory?forum=winserverGP
============================================
If the Answer is helpful, please click "Accept Answer" and upvote it.
Note: Please follow the steps in our documentation to enable e-mail notifications if you want to receive the related email notification for this thread.