@Roberto Sitzia Thank you for reaching out to Microsoft Q&A.
I understand that you want to setup selective access to P2S VPN AD users and wanted to know how to go about the same.
This is possible via Azure MFA or Azure Conditional Access both of which can provide you per user/per group access to the P2S VPN as needed. Please refer to this document for more details regarding the same.
Hope this helps. Please let us know if you have any further questions and we will be glad to assist you further. Thank you!
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