1.If we use mstsc to remote access destination server like below picture, will the same issue happen?
2.Does this end user's 2 monitors have the same resolution?
3.Did you try to update the display card driver for your issue PC?
4.If we create a new local admin accoun, will the same issue happen on this new lcoal admin account?
There are other document for your reference
CITRIX - USING MULTIPLE MONITORS
Span on multiple monitors when logged into a Citrix session via Citrix Receiver (or Citrix server)
If the issue persist, we can also post this issue in Citrix forum.
Problem with Citrix Workspace for Windows and multiple monitors
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