Using Classic Outlook on Windows for personal email, calendar, and contact management
Hello Vo Hoang Khang,
Thank you for posting this case in Microsoft Community!
Based your description, you have setting auto reply email with specified template by Rule Wizard, you want to know if possible to send only one time when I received new email and don't repeat when someone reply your old email. I would like to cooperate with you working on this case.
To clarify this case, this case is related to Outlook Rules Wizard which allows you to "run a script" when you create a specific rule. You may check this Microsoft article as reference: How to create a script for the Rules Wizard in Outlook
But this case could be solved by the developer, you may check with some more development resources. I am so sorry for having limited resource on development issues, if need more assistance, please go to: Microsoft Developer
Your understanding and patience will be appreciated.
Thank you!