For now, you have not encountered similar errors on the latest system, right?
Since this MSI file is developed, you probably did something that Defender found suspicious.
If you are unable to reproduce the problem at this time and you have not encountered an error in other similar systems, then it is likely to be a be a false positive.
One explanation for a false positive is that Microsoft Windows Defender may not have enough information about the file to determine that it is safe.
False positives/negatives can occur with any threat protection solution, including Microsoft Defender
Hope above information can help you.
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