@balanarasimha c Thank you for reaching out to Microsoft Q&A.
I understand that you are having issues with connecting to the Azure P2S VPN when connecting from a remote machine that is in the wifi network but not if it is in the mobile network, please correct me if I am wrong.
This is commonly seen when using home routers and firewalls as they may block certain ports/protocols. I would suggest you to look into the same and determine that the respective ports/protocols are being allowed in the local network. Hope this helps.
Please let us know if you have any further questions and we will be glad to assist you further. Thank you!
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