A family of Microsoft relational database management systems designed for ease of use.
I'd ditch the 'Select one' default value from the second combo box, but regardless of that, in the AfterUpdate procedure of the first combo box you should not only requery the second, but set it to Null. If a value has been selected in it and the user then goes back and selects another value in the first combo box, that in the second will probably be inappropriate to that in the first. Moreover, if the bound column of the second combo box is hidden it will appear empty, but will still have the inappropriate value.
You should validate the the second combo box is not Null in the form's BeforeUpdate event procedure. This has a Cancel argument whose return value can be set to true if the second combo box is Null, forcing the user to enter a value before the record can be saved.
More fundamentally, if both combo boxes are bound controls consider whether storing both values introduces redundancy, e.g storing both CityID and State values does this as the former determines the latter. You'll find a demo of ways of handling this at:
using the local administrative areas off parish, district and county in my neck of the woods.
Ken Sheridan, Stafford, England