Your words " if one of the columns is blank, I need it to say "Yes"" lead me to believe that your should change the AND to OR:
=IF(OR(COUNTBLANK(K2:V2)>0,(OR(K2>179,L2="G",M2="G", N2="G", O2="G", P2="G", Q2="G", R2>2, S2>2, T2>44,U2>2,V2<=V207))),"Yes","No")
But to better understand why your last row is giving a "Yes" rather than "No", we would need the entire last row's values (with identification of the columns) - though is seems that 322 is greater than 179 - OR - maybe you need to change V2<=V207 to V2<=V$207
- OR...... Though to really help, we would need a description (in words) or what your requirements are.
Nate that you can shorten the check for "G" parts by using COUNTIF:
=IF(OR(COUNTBLANK(K2:V2)>0,(OR(K2>179,COUNTIF(L2:Q2,"G")>0, R2>2, S2>2, T2>44,U2>2,V2<=V207))),"Yes","No")
Another technique is to set the requirement for each column or set of columns by individual formulas that return TRUE or FALSE - when they all return TRUE (Checking with another formula), then you can say "Yes" That makes the logic a little clearer.
HTH, Bernie