A family of Microsoft relational database management systems designed for ease of use.
I'm thinking the install on Vista went wrong. "Not a valid win32 application" is a very serious error indicating the EXE is damaged or was never meant to be run on Win32 (e.g. an Apple or Linux EXE). Could be a virus.
As another test you could copy the exe from a working machine to the Vista machine in a temp folder, open a Command window, then run fc.exe to do a file compare. Run "fc.exe /?" to get help on the arguments.