I solved this by using ADMX for Chrome and Firefox; you can define mailto handler easly :
For Chrome : [{"url":"https://zimbra.contoso.com/?view=compose&to=%s","default": true,"protocol":"mailto"}]
For Firefox : {"schemes":{"mailto":{"action":"useHelperApp","ask":false,"handlers":[{"name":"zimbra.contoso.com","uriTemplate":"https://zimbra.contoso.com/?view=compose&to=%s"}]}}}
And create this reg key :
HKCU\Software\Microsoft\Windows\Shell\Associations\UrlAssociations\MAILTO\UserChoice]
"Progid"="ChromeHTML"
or
HKCU\Software\Microsoft\Windows\Shell\Associations\UrlAssociations\MAILTO\UserChoice]
"Progid"="FirefoxURL"
Tested on 2008R2, 2019 Server Std with last Chrome and Firefox version and Firefox EST last version