Hi,
Thanks for reaching our forum. Yes, you could achieve User profile Disk high availability by storing them in Azure with Storage Spaces Direct.
Per below link, it is recommended that:
- For small deployments, a 2-node cluster with a cloud witness, where the volume is mirrored with 2 copies.
- Grow small deployments by adding data disks.
- Grow larger deployments by adding nodes (VMs).
Please go and check the detailed steps and requirements for deploying a two-node Storage Spaces Direct scale-out file server for UPD storage.
Some reference links:
https://learn.microsoft.com/en-us/windows-server/remote/remote-desktop-services/rds-storage-spaces-direct-deployment
https://www.tech-coffee.net/rds-2016-farm-configure-file-servers-for-user-profile-disks/
Please note: Information posted in the given link is hosted by a third party. Microsoft does not guarantee the accuracy and effectiveness of information.
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Thanks,
Jenny