A family of Microsoft relational database management systems designed for ease of use.
The easiest way I can think of is by enlisting the help of Excel: http://www.mrexcel.com/forum/excel-questions/347468-multiple-linear-regression-visual-basic-applications.html
This tool also supports it: https://www.fmsinc.com/MicrosoftAccess/DataAnalysis/regression/index.html
Plenty of other options to explore when you search the internet for "multiple regression vba"