Hi Aaron,
Please check this article to troubleshoot. You may remove the links that are in question.
If the issue persists, could you please provide the following information to help better understand your situation?
- A screenshot of the error message. Is it from Excel application (Windows or Mac?) or Excel Online?
- If you create a new blank workbook, does the issue occur?
- Does the issue occur to all the workbooks?
- About "unable to open the files in Excel (2016)", please provide detailed steps and related screenshots about how you encounter the issue. Do you open the files in SharePoint site library with Excel application via browser?
Thanks,
Tina