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Hi Ryan,
Please try checking the followings to see if there is any difference:
1. Reset browsers and clear caches. For example, Reset Internet Explorer Settings.
2. Try different browsers.
If the same behavior appears, we need to confirm few things to better understand your situation:
1. Does this only happen to one specific Workbooks or all workbooks? Please try a).creating a new blank document b).copying the content to a new document to see if it exhibits same behavior.
2. Does this happen to other document libraries on the same site and other sites?
3. Try a different network environment to see if there's any improvement.
4. Please help capture a screenshot of "quite often hangs with a grey screen and "working on it.." message".
Regards,
Joanne