Microsoft 365 features that help users manage their subscriptions, account settings, and billing information.
Hi Joshua Horn,
Generally, Office 365 ProPlus includes Office suite and Office Online, also OneDrive for Business can provide file storage and sharing function and so on. It's more compatible for personal usage.
For Office 365 Enterprise E3, it includes all above in Office 365 ProPus and it's more compatible for an organization, such as a company. You should have Office 365 for Business account and have unified management.
If you still have any concern about it, feel free to let us know.
Thanks,
Iry