Hi Donna,
If only this file has this issues, we suggest you open it in protect view and copy the content into a new blank workbook created in Office 365, then save the new workbook instead.
.xls is an old format from Excel 97-2003, it might cause some issues when processing it in the newer version of Excel. If you would like to use the original workbook, you could try converting it to .xlsx first:

About the macros in the excel file, if you think you could use the workbook without them, you could just save it as .xlsx although it will pop up an error to remind you that the macros will not be kept in the workbook.
If you still cannot save the workbook, could you share us a copy of it for further troubleshooting? To protect your privacy, please send it via private message:
https://answers.microsoft.com/en-us/privatemessage/inbox.
Regards,
Alex