A family of Microsoft spreadsheet software with tools for analyzing, charting, and communicating data.
If you feel something has got corrupted, you need to prepare a new workbook and move the values from old workbook to new one.
However, optimizing excel workbook will require you to go throgh some literarature on this. This will be value adding to you also.
Most of your questions are answered at below links -
Excel 2010 Performance: Improving Calculation Performance - http://msdn.microsoft.com/en-us/library/ff70051...
Excel 2010 Performance: Performance and Limit Improvements - http://msdn.microsoft.com/en-us/library/ff70051...
Excel 2010 Performance: Tips for Optimizing Performance Obstructions - http://msdn.microsoft.com/en-us/library/ff72667...
Excel Calculation Bottlenecks - http://www.decisionmodels.com/optspeedd.htm
Top 10 List of Performance Issues in Excel Workbooks - http://blogs.technet.com/b/the_microsoft_excel_...