Hi @Jen ,
Check IIS to make sure it has installed ASP.NET. Like this:
Which ASP.NET do you use? 2.0, 3.5 or 4.8?
As an administrator, run the command "%systemroot%\Microsoft.NET\Framework\v2.0.50727\aspnet_regiis -i". Then reset IIS.
Check Url rewrite rule or application route to make sure request wasn't redirected to other.
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Best regards,
Bruce Zhang