There is no WASM support. WASM is a vm sandbox implemented by the browser. It is currently not implemented by WebView controls used by Windows and MacOs applications. If WASM becomes popular enough, the WebViews may add support. There are requests for Electron to support WASM.
While the office apps could add their own WASM support, WASM apps would not be practical with Online Office (as only one WASM is supported per site). It would make more sense to request direct Blazor support in office apps, but again there is the issue of online apps (but there is a javascript interpreter for WASM which can host blazor code).
While office applications do not officially support blazor, you may be able to get the server version to work. Currently Fluent UI React is the preferred solution:
https://learn.microsoft.com/en-us/office/dev/add-ins/design/using-office-ui-fabric-react
but if you want non react then use fabric core
https://learn.microsoft.com/en-us/office/dev/add-ins/design/fabric-core
note: As WASM has no access to the network or dom except calling JavaScript via messages, I don’t see how it can be more sophisticated.