Hi Danny Egan ,
First, my pleasure to assist you.
As per your description, please don’t worry we can work together to narrow down and resolve the situation.
It seems you are Excel built-in template for “Equipment inventory” template.
I totally understand the using Excel inventory template there are most cells have constant comment popups that keep displaying when those cells are selected, and you want to remove or edit them.
I will help you to remove pop-up comments in Excel template. First, I would like to explain these are not comments but these are Data Validation Messages.
Please follow my step below to meet your requirement.
1.Select the cell where pop up message is appearing >click on Data tab > Data Validation > The pop message is in the Input Message > Either you can remove messages via select the text/message and delete or just click on “clear all”.
See image below for your reference:

To remove them in block:
- Select rows e.g. 1 to 7 > Data tab > Data Validation > Clear All
- Select rows e.g. 20 to 22 > Data tab > Data Validation > Clear All
I appreciate your understanding and stay safe!!
Best regards
Waqas Muhammad