Hi noname_483
Welcome to Microsoft Community.
Based on your description, don't worry, we can work together to keep getting closer to the answer.
According to the category Microsoft 365 and office software you posted, we can know that your problem is "After changing the settings before, and selecting the display worksheet from right to left, the new Excel worksheet will be automatically displayed from right to left" if My understanding is wrong, feel free to correct me. I can understand that sometimes it's annoying that something goes wrong, and the fact that it hasn't been resolved is frustrating.
According to your situation, we found this option in Office 365. Did you check this option before, as shown in the following screenshot:
We may trouble you to provide more detailed information. After you create a new Excel worksheet, whether this option is still checked? If still checked. It may be that your Excel component has a certain setting failure. We recommend that you reset the Excel program to return the application to an initial state, and then check whether there is a problem. You can follow the steps below, I hope it will help you:
1. Quit all Office programs
2. Make sure there are no files in the following folders:
1) Navigate to C:\Users\username\AppData\Roaming\Microsoft\Excel\XLSTART, press Enter to check if there is a file, if so, delete it, if not, close it;
2) Navigate to C:\Program Files\Microsoft Office\root\Office16\XLSTART or C:\Program Files(x86)\Microsoft Office\root\Office16\XLSTART to see if there is a file, if so, delete it as well , if not, close;
3. Press and hold Windows key + R key at the same time, enter regedit, and press Enter;
4. Navigate to the following keys in turn, and rename the word folder (right-click it and select Rename, such as renaming Excel to Excelold);
HKEY_CURRENT_USER\Software\Microsoft\Office\16.0\Excel
HKEY_CURRENT_USER\Software\Microsoft\Office\Excel
5. After doing the above, review the problem.
Disclaimer: Generally, modifying registry subkeys or work group is intended for advanced users, administrators, and IT Professionals. It can help fix some problems, however, serious problems might occur if you modify the registry incorrectly. Therefore, make sure that you follow these steps carefully. For further protection, back up the registry before you modify it. Then, you can restore the registry if a problem occurs. For more information about how to back up and restore the registry, click hereto view the article.
I hope this helps you, feel free to contact us if you have any further questions
Chandy| Microsoft Community Support Specialist
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