Dumisile Mthalane,
From your description it sounds like the file is corrupt. Are you saving locally or to a remote server? Operating a Project file over a network is susceptible to network glitches.
Is the file a single Project file or does it have links to other files (e.g. part of master/subproject, resource pool/sharer, paste links, etc.)? Linked structures in Project are prone to corruption.
If you have a backup for your file I suggest you open it, save as XML, and then open the XML file in Project. That often clears corruption but not always.
John