A family of Microsoft spreadsheet software with tools for analyzing, charting, and communicating data
I don't have any files quite that large but I do have one which is 42.8MB (19 Columns x 228627 Rows). I haven't been able to reproduce the issue [Microsoft 385 v16.66.1 on macOS 12.6].
Please clarify what you mean by "...switching my filters". Exactly what steps are you taking? Specific details are important.