A family of Microsoft spreadsheet software with tools for analyzing, charting, and communicating data
Dear maxt41,
Good day! Thank you for posting your query in our community.
Based on your description, you can't open Excel application on the specific device.
Since you have already tried most of the suggestions, you can perform a clean boot in Windows which is different with the Windows safe mode to check whether a background program is interfering with Office program.
If the problem persists, to check whether the problem might be related to the old user profile, you can try to switch to a new Windows User Profile. This method can rule out the possible reason of your current Windows User Account.
Sincerely,
Jazlyn | Microsoft Community Moderator