Hello Edwin B! I'm Gunasekar and I'd be happy to help you with your question.
I understand that you are experiencing issues with the Excel Program running on your Windows 10 Operating system. You could try the following suggestions below and check if it helps.
- Run the Program in safe mode.
When you run Excel in safe mode, it bypasses functionality and settings such as alternative startup location, changed toolbars, startup folders used by Excel, Excel add-ins, and most COM add-ins. While add-ins can enhance your experience, they can occasionally interfere, or conflict with Excel.
To open Word in safe mode, Click Windows Key + R altogether,
Type excel /safe
Click enter.
If the issue appears on safe mode, repair the Office applications.
- Repair Office applications.
A. Click Start and select Settings.
B. Click Apps and Features.
C. Find Microsoft Office 365 in the lists, and click three dots next to it.
D. select Modify.
E. Perform an Online repair.

When it is done, Restart your PC.
If the issue persists, perform the troubleshooting methods discussed in the article below.
- Excel not responding, hangs, freezes or stops working (Related Microsoft self help article for your reference)
https://support.microsoft.com/help/37e7d3c9-9e84-40bf-a805-4ca6853a1ff4
I hope this information helps. If you have any questions, please let me know and I will be happy to help you further.
Best regards,
Gunasekar N