Hi Kelly,
Welcome to Microsoft Community.
Since Excel does not have a built-in function to directly retrieve the last row of the current worksheet, it is not straightforward to dynamically and automatically determine the length of the dataset. You may consider manually updating the range for conditional formatting or setting the range accordingly.
Select your dataset range, for example, B3:B500. Please note that you should not start from B2 because the first row is the header row, and B2 does not have a "top-right" cell to compare with. B500 is a simulated endpoint for a larger dataset. If your dataset exceeds 5000 rows, you can extend it to B1000, B2000, and so on.
Create a new conditional formatting rule > "Use a formula to determine which cells to format" > Enter the following formula:
=AND(B3<>"", B3<>C2)
Choose your desired highlight color and save the rule.
I hope this works effectively for you as well.
If you have any other questions or want to share more context, please let me know in your reply!
Best Regards,
Thomas C - MSFT | Microsoft Community Support Specialist