Hi QUYENND-4075,
Thanks for your posting on Q&A.
If the IIS has not been configured before, please refer to the links below to configure it on the both downstream and upstream WSUS Server first:
https://support.microsoft.com/en-us/help/4490414/windows-server-update-services-best-practices
Please try to restart the Application Pools and then try to resync again.
If you have any feedback about this case, please let me know.
Regards,
Rita