Hi,
We do not recommend to use third party software to create system image, Microsoft Sysprep would be helpful for you to create system image which used on deploy image to computer.
For deleting this folder issue, did you uninstalled the third party software? If not, try to uninstall it at first.
Disable antivirus software especially third party antivirus software.
Is it available to delete other files on same drive?
As I noticed you could delete some file but persists with "access deny" error message, so please run the following command line to take own and check the issue again.
takeown /f file_name
icacls file_name /grant username_or_usergroup:F /q
If the issue persists, please right click the folder, and choose properties\Security\Advanced, make sure you are owner of this folder.
Or you could create a capture and paste it here.
As some registry key missing will cause access deny error, we could use Procmon tool to monitor deleting process, then analysis the Promon thread to check for more details.
Bests,