Hi,
Since you are using the Windows 10 Home, the GPO method maybe not helpful.
From the hardware, you could physically remove them or fill them with something.
Or you could disable the use of USB storage devices by Registry Editor:
Running regedit in the Run dialog box.
Go to Computer\HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\USBSTOR, and then locate the DWORD value named ''Start'' on the right-side pane. The default value data of Start is ''3''. Double-click on Start, and set its value data to ''4''.
Restart Windows 10 to see if it works.
Hope above information can help you.