Hi @Desmond W ,
I use the Office 16 desktop version of Outlook.
Windows 10
Dell Latitude tablet
Sorry that I don't have a same Dell Latitude tablet to check the result, but when checking on my PC with Outlook 2016 running on Windows 10, "CTRL+Shift+M" still works for me. And reading this document, "CTRL+Shift+M" is still listed as the shortcut keys for creating a new mail.
For your situation, was there any change made on the device right before the issue occurred? Have you installed any new software which might have a hotkey conflict with Outlook?
Besides, instead of using "CTRL+Shift+M", an alternative we can use is to press "Ctrl+N" (when in Mail view) to create a new message. And if you would like to create a new mail when in another view, we can quickly swich to Mail view by pressing Ctrl+1 and then use Ctrl+N to create a new message.
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