Why can our WPF application not interact with printers if it is run as administrator?

Question

My team makes a WPF application that interacts with several external peripherals. Two of said peripherals are a receipt printer and a cannon picture printer. Lately, we have encountered an interesting problem:

If the application is run as an administrator, neither of the printers work.

If the application is not run as an administrator, both printers work as expected.

It is kind of the opposite of what I would expect, as admins have elevated privileges. If anybody has experienced this behavior and can provide any insight, it would be greatly appreciated.