A family of Microsoft spreadsheet software with tools for analyzing, charting, and communicating data.
Are you referring to both downloading as well as opening or are you using the terms interchangeably?
It is recommended to not open Office documents stored on iCloud or other cloud services – they are fine for storage & archiving but they aren't designed to support the complexity of Office user files. Numerous reports indicate that it can lead to corruption & data loss. Always download the to the local HD then upload the file once you have finished & saved the file.