Hi Micheal Swart,
You are perfectly safe to proceed with the deletion directly from the User Profiles Settings window. When a user is removed from your Active Directory domain controller, the local server loses its ability to translate their Security Identifier (SID) into a readable username. Because the Active Directory object no longer exists to provide that translation context, the server displays the profile as an Unknown Account. This is standard enterprise behavior and confirms the domain deletion was successful.
Executing the removal through this graphical interface is the exact Microsoft best practice because it performs a complete and clean removal. Behind the scenes, the operating system securely deletes the physical user folder from the C:\Users directory while simultaneously diving into the registry to sever the connection located at HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\ProfileList.
Manually deleting the folder via File Explorer is strongly discouraged. Doing so leaves the aforementioned registry keys orphaned in the ProfileList hive, which frequently causes temporary profile errors, such as users being logged into temporary profiles during future sessions. Relying on the System Properties window ensures your server reclaims space without risking any registry corruption or lingering system conflicts.
Hope this answer has brought you some useful information. If it did, please hit “accept answer”. Should you have any questions, feel free to leave a comment.
VPHAN